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Diclofenac may increase the risk of heart disease: study

A recent study conducted by scientists at University of Toronto, Canada and University of Newcastle, Australia suggests that a popular painkiller Diclofenac can increase the risk of heart diseases. They compared other well studied non-steroidal anti-inflammatory drugs like Rofecoxib, Ibuprofen, and Naproxen viz-a-viz Diclofenac. The findings suggest that the highest risk of cardiac disease was seen with Rofecoxib, followed closely by Diclofenac. On the other hand, Ibuprofen and Naproxen were found to be safer.
The effects were investigated based on dosages of each drug. Interestingly Naproxen was found to be risk-neutral at all doses and Ibuprofen risk was seen only with higher doses.
This study is published in PLoS Medicine.